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Publication in Advanced Materials:

June 12 2023

The ENLIGHT peer-reviewed publication by UMC Utrecht: Shaping Synthetic Multicellular and Complex Multimaterial Tissues via Embedded Extrusion-Volumetric Printing of Microgels gained media attention this month.

Full article here: https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.202301673

EurekaAlert press release: https://www.eurekalert.org/news-releases/991737

🔥 Hot from the press: new report describing the synergy between extrusion bioprinting and volumetric bioprinting: unveiling Embedded extrusion Volumetric Printing (EmVP), a work carried by Davide Ribezzi.
Multi-material and multi-cellular complexity is now easily possible also in tomographic 3d printing ! 
The paper describing this work is now online open access in Advanced Materials Wiley.

We developed microgel bioresins, expanding the materials library for VBP into the world of granular gels. This allows to create hierarchical, microporous environments that facilitate cell growth. The rheological behavior of the microgel slurry allows it to act as a support bath for suspension extrusion bioprinting, and to position pockets and arbitrary patterns of cells (at high density) and materials in specific regions within the construct. As the microgels are photosensitive, volumetric printing allows to shape the construct into its final geometry in a matter of few seconds. In this study, we also delved into applications of synthetic biology for biofabrication, engineering light-responsive pancreatic beta cells, and creating a model to study the cross-talk between insulin supply and adipogenesis in mesenchymal stromal cells.

A fantastic collaborative work with the European Research Council (ERC), VOLUME-BIO project at the Regenerative Medicine Utrecht and partners within the ESMEA European Small and Medium-sized Enterprises Association e.V. – funded, ENLIGHT consortium, Marième Gueye, Sammy Florczak, Massimiliano Caiazzo, Martin Fussenegger, Andreas Hierholzer, Dieuwke de Vos, Jos Malda Francesca Manente , and the colleagues from Universitätsklinikum Würzburg: Franziska Dusi Torsten Blunk.